Iridium-catalyzed selective α-methylation of ketones with methanol.
نویسندگان
چکیده
Iridium-catalyzed selective α-dimethylation and α-methylation of ketones or phenylacetonitriles, using methanol as the methylating agent, were achieved. In addition, three-component cross α-methyl-alkylation was successfully performed using methyl ketones with methanol and primary alcohols with long-chain alkyl groups. This method provides a very convenient direct route to α-methylated ketones, using methanol.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 50 19 شماره
صفحات -
تاریخ انتشار 2014